Deletion and over-expression of gene studies suggest that GDF11 plays a primary role in regulating the skeletal system’s embryological development. There’s evidence indicating its potential role in central nervous system development, blood vessel formation, kidney development, and other tissue functions.
GDF11 has shown promise in improving outcomes for neurodegenerative and neurovascular diseases, promoting increased skeletal muscle volume, and enhancing muscle strength. Its broad spectrum of biological effects might extend to clinical applications aimed at reversing senescence and addressing age-related pathological changes, possibly facilitating organ regeneration following injury.