Thymosin-β4 FRAGMENT 1-4 10 mg (Without Mannitol)

Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food, or cosmetic.
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The initial four amino acids within Tβ4 modulate its anti-inflammatory and antifibrotic effects. Tβ4 demonstrates significant effects in alleviating inflammation. For instance, in a mouse model of autoimmune encephalomyelitis, Tβ4 treatment notably reduced the number of inflammatory cells within the brains, as observed through hematoxylin-eosin staining. Moreover, in models related to liver injury induced by ethanol and lipopolysaccharide, Tβ4 impeded the activation of nuclear factor kappa B (NF-κB) by inhibiting the phosphorylation of the inhibitory protein IκB. This action effectively prevented the production of proinflammatory cytokines like tumor necrosis factor-α (TNF-α), IL-1β, and IL-6. Furthermore, in a neonatal mouse model of fetal alcohol spectrum disorder, Tβ4 treatment demonstrated an inhibitory effect on the increase in inflammatory factors triggered by ethanol, leading to reduced expression levels of TNF-α and IL-1β.