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What is the
Difference Between
GHK and GHK-Cu?
GHK with and without copper affects a large number of genes related to an organism’s response to stress and injury (tissue remodeling, anti oxidant, anti-inflammatory, anti-pain, anti-anxiety, blood vessel growth, nerve outgrowth, anti-cancer action). GHK sequence is included in the collagen molecule, and SPARC protein and GHK is naturally released after an injury due to protein breakdown. Copper is a transitional metal that is vital for all eukaryotic organisms from microbes to humans. Since it can be converted from oxidized Cu(II) to reduced Cu(1) form, it functions as an essential cofactor in a multitude of biochemical reactions involving electron transfer. A dozen enzymes use changes in copper oxidation states to catalyze important biochemical reactions, including cellular respiration, antioxidant defense, detoxification, blood clotting, and the connective tissue formation. Copper is required for iron metabolism, oxygenation, neurotransmission, embryonic development and many other essential biological processes.
GHK, a tripeptide consisting of glycyl-histidyl-lysine in its amino acid sequence, is naturally present in human plasma, saliva, and urine. Its concentration in plasma typically measures around 200 ng/mL at the age of 20, diminishing to approximately 80 ng/mL by the age of 60. This reduction in GHK levels aligns with the observable decline in an organism’s regenerative capabilities. Extensive scientific investigations have unveiled GHK’s potential role in aiding wound healing, managing infections, promoting hair growth, addressing aspects of cancer, supporting cognitive health, and exploring cosmetic applications for facial enhancement.
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