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Sequence one letter code: SALLRSIPAPAGASRLLLLTGEIDLP
Sequence three letter code: H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH
CAS registry number: 867021-83-8
Molecular Formula: C119H206N32O35
Molecular Mass/ Weight: 2645.3
This novel peptide, colivelin, was engineered to enhance the neuroprotective capabilities of humanin (HN). It combines Activity-Dependent Neurotrophic Factor (ADNF) with AGA-(C8R) HNG17, a robust HN derivative. Colivelin has demonstrated remarkable potential by entirely halting cell death triggered by overexpressed genes causing Familial Alzheimer’s disease (FAD) and beta-amyloid (1-43). When administered intraperitoneally, colivelin effectively mitigates memory impairment, presenting itself as a promising candidate for the treatment of Alzheimer’s disease.
