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GDF11 (Growth Differentiation Factor 11) is a naturally occurring protein in the TGF-β (Transforming Growth Factor-beta) superfamily. It plays a key role in cellular differentiation, tissue regeneration, and age-related repair mechanisms. Initially active during embryonic development, GDF11 has gained attention in longevity research due to its potential to rejuvenate aging tissues, particularly in the brain, skeletal muscle, and cardiovascular system.