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Humanin Structure
Source: Pubchem Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-lle-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Molecular Formula: C119H204N34032S2
Molecular Weight: 2687.3 g/mol
PubChem SID: 16131438
CAS Number: 330936-69-1
Synonyms: formyl humanin, HNGF6A protein
Humanin, a naturally occurring micro-peptide, stands out for being encoded within mitochondrial DNA—an exclusive genetic segment present solely within mitochondria. Its primary function involves serving as a cytoprotective agent, safeguarding cells against apoptosis (programmed cell death) by disrupting the typical functions of the Bcl2-associated X protein (Bax). Variants of humanin have been identified across various mammals, exhibiting a high degree of conservation among different species[1]. Scientific investigations emphasize the significance of humanin in shielding neurons, cardiac tissue, muscle cells, the eye’s retina, and the endothelial lining of blood vessels.
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