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IGF1-LR3 Structure
Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK
PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
Molecular Formula: C400H625N1110115S9
Molecular Weight: 9117.5 g/mol
CAS Number: 946870-92-4
IGF1-LR3 stands as a modified variant of insulin-like growth factor-1, known by its complete designation as insulin-like growth factor-1 long arginine 3. All derivatives of IGF-1 significantly contribute to cellular division, proliferation, and intercellular communication. Despite sharing similar effects, IGF-1 LR3 exhibits a weaker binding affinity to IGF binding proteins in comparison to IGF-1. Consequently, IGF1-LR3 remains in circulation around 120 times longer than IGF-1. This prolonged half-life of IGF1-LR3 stems from structural modifications; the peptide’s formulation involves the addition of 13 amino acids to the N-terminal end of IGF-1 and the transformation of glutamic acid at position 3 of IGF-1 into an arginine residue.
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