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Cortagen Structure
Amino Acid Sequence: Ala-Glu-Asp-Pro (AEDP)
Molecular Formula: C₁7H27N5O8
Molecular Weight: 430.17 g/mol
PubChem CID: 18439621
Synonyms: SCHEMBL5491754
Cortagen (Ala-Glu-Asp-Pro) is part of the family of “Khavinson peptides,” a group comprising short peptides typically spanning 2 to 4 amino acids. These peptides exhibit robust bioregulatory functions and frequently induce alterations in tissue-specific gene expression patterns. Discovered by Vladimir Khavinson, Cortagen primarily operates within the central nervous system while also demonstrating secondary effects in the heart and immune system. Studies indicate that Cortagen plays a role in stabilizing the inflammatory response in the central nervous system, contributing to the equilibrium between pro- and anti-inflammatory pathways. Animal research suggests that Cortagen diminishes the enduring effects of ischemic injury in the brain and aids in restoring nerve function subsequent to transection or injury. Notably, Cortagen acts as a geroprotective and anti-aging peptide, contributing to DNA restoration toward a more youthful state, reducing senescence, and enhancing the expression of specific genes often suppressed with age.