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Melanotan 1 Structure
Sequence: Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val
Molecular Formula: C78H₁N21O19
Molecular Weight: 1646.874 g/mol
PubChem CID: 16154396
CAS Number: 75921-69-6
Synonyms: Afamelanotide, Scenesse, CUV1657, MT-1
Melanotan 1, a synthetic analogue derived from alpha-melanocyte stimulating hormone, is clinically utilized in Europe to prevent sun-induced skin damage, particularly phototoxicity, in individuals affected by erythropoietic protoporphyria. Initially formulated as a sunless tanning solution, Melanotan 1 exhibits various physiological effects on blood pressure, feeding patterns, central nervous system functionality, and more. Currently, the peptide is undergoing phase 3 clinical trials for treating polymorphose light eruption and is in phase 2 trials for managing actinic keratosis—a specific sun-induced skin damage condition—and its severe variant, squamous cell carcinoma.
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