KCF-18 (10mg)
$126.50
- Sequence
- H-Lys-Cys-Arg-Lys-Glu-Met-Phe-Lys-Gln-Lys-Leu-Pro-Tyr-Val-Tyr-Phe-OH
- Molecular Formula
- 2296.74 g/mol
- Molecular Weight
- C107H166N26O26S2
For laboratory research use only. Not for human use.
- Lyophilized peptides should be reconstituted using proper aseptic laboratory technique.
- Reconstitution must be performed using Canlab-supplied Bacteriostatic Water and handled in accordance with generally accepted research practices.
- Warranty related to reconstitution, sterility or material integrity applies only when Canlab Bacteriostatic Water is used.
- Use of third-party diluents or deviation from the provided handling guidance voids any applicable warranty.
For full handling instructions and limitations, see the Peptide Reconstitution, Research Use Only section in our Product Warranty Policy Page →
Description
KCF-18 inhibits cytokine-induced inflammatory response. It has amphiphilic properties (positively charged and hydrophobic residues) derived from the receptors of proinflammatory cytokines. The lab studies report KCF-18:
- Binds to cytokines simultaneously, with electrostatic interactions being the dominant mechanism
- Significantly reduces the binding of proinflammatory cytokines (TNF-alpha, IL-6) to their cognate receptors
- Suppresses TNF-α mRNA expression and monocyte binding and transmigration
- Alleviates the infiltration of white blood cells (in a peritonitis mouse model)
Studies support that KCF-18 could remarkably diminish the risk of vascular inflammation by decreasing plasma cytokines release and by directly acting on the vascular endothelium.
Additional Information
Benefits
Please review the complete product description and available supporting documentation for product-specific research information. This product is sold strictly for laboratory research use.
Mechanism of Action
Refer to the product description, certificate of analysis and applicable published research for product-specific information. No medical or therapeutic claims are made.
