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KCF-18 (10mg)

KCF-18 (10mg)

$126.50

Reconstitution Warranty Notice (Research Use Only)

For laboratory research use only. Not for human use.
Lyophilized peptides should be reconstituted using proper aseptic laboratory technique.
Reconstitution must be performed usingย Canlab-supplied Bacteriostatic Waterย and handled in
accordance with generally accepted research practices.
Warranty related to reconstitution, sterility, or material integrity applies only when Canlab
Bacteriostatic Water is used.ย Use of third-party diluents or deviation from provided handling
guidance voids any applicable warranty.
For full handling instructions and limitations, please refer to the Peptide Reconstitution, Research Use Only section in our

Product Warranty Policy Page

KCF-18 Structure

Peptide Sequence: H-Lys-Cys-Arg-Lys-Glu-Met-Phe-Lys-Gln-Lys-Leu-Pro-Tyr-Val-Tyr-Phe-OH ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  ย  Molecular Formula: 2296.74 g/mol
Molecular Weight: C107H166N26O26S2

Description

KCF-18 inhibits cytokine-induced inflammatory response. It has amphiphilic properties (positively charged and hydrophobic residues) derived from the receptors of proinflammatory cytokines. The lab studies report KCF-18:

  • Binds to cytokines simultaneously, with electrostatic interactions being the dominant mechanism
  • Significantly reduces the binding of proinflammatory cytokines (TNF-alpha, IL-6) to their cognate receptors
  • Suppresses TNF-ฮฑ mRNA expression and monocyte binding and transmigration
  • Alleviates the infiltration of white blood cells (in a peritonitis mouse model)

Studies support that KCF-18 could remarkably diminish the risk of vascular inflammation by decreasing plasma cytokines release and by directly acting on the vascular endothelium.

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