Thymosin-β4 FRAGMENT 1-04 (10mg)
$125.00
- Lyophilized peptides should be reconstituted using proper aseptic laboratory technique.
- Reconstitution must be performed using Canlab-supplied Bacteriostatic Water and handled in accordance with generally accepted research practices.
- Warranty related to reconstitution, sterility or material integrity applies only when Canlab Bacteriostatic Water is used.
- Use of third-party diluents or deviation from the provided handling guidance voids any applicable warranty.
For full handling instructions and limitations, see the Peptide Reconstitution section in our Product Warranty Policy Page →
Description
The initial four amino acids within Tβ4 modulate its anti-inflammatory and antifibrotic effects. Tβ4 demonstrates significant effects in alleviating inflammation. For instance, in a mouse model of autoimmune encephalomyelitis, Tβ4 treatment notably reduced the number of inflammatory cells within the brains, as observed through hematoxylin-eosin staining. Moreover, in models related to liver injury induced by ethanol and lipopolysaccharide, Tβ4 impeded the activation of nuclear factor kappa B (NF-κB) by inhibiting the phosphorylation of the inhibitory protein IκB. This action effectively prevented the production of proinflammatory cytokines like tumor necrosis factor-α (TNF-α), IL-1β, and IL-6. Furthermore, in a neonatal mouse model of fetal alcohol spectrum disorder, Tβ4 treatment demonstrated an inhibitory effect on the increase in inflammatory factors triggered by ethanol, leading to reduced expression levels of TNF-α and IL-1β.
Additional Information
Benefits
Please review the complete product description and available supporting documentation for product-specific research information.
Mechanism of Action
Refer to the product description, certificate of analysis and applicable published research for product-specific information. No medical or therapeutic claims are made.
