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Name: Thymosin-β4 FRAGMENT 1-04 (10mg)
SKU: CL-THYMOSINB4FRAGMENT1/4-10MG
Availability: InStock

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Peptides

Thymosin-β4 FRAGMENT 1-04 (10mg)

$125.00

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Reconstitution Warranty Notice (Research Use Only)

For laboratory research use only. Not for human use.

Lyophilized peptides should be reconstituted using proper aseptic laboratory technique.
Reconstitution must be performed using Canlab-supplied Bacteriostatic Water and handled in accordance with generally accepted research practices.
Warranty related to reconstitution, sterility or material integrity applies only when Canlab Bacteriostatic Water is used.
Use of third-party diluents or deviation from the provided handling guidance voids any applicable warranty.

For full handling instructions and limitations, see the Peptide Reconstitution, Research Use Only section in our Product Warranty Policy Page →

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Description

The initial four amino acids within Tβ4 modulate its anti-inflammatory and antifibrotic effects. Tβ4 demonstrates significant effects in alleviating inflammation. For instance, in a mouse model of autoimmune encephalomyelitis, Tβ4 treatment notably reduced the number of inflammatory cells within the brains, as observed through hematoxylin-eosin staining. Moreover, in models related to liver injury induced by ethanol and lipopolysaccharide, Tβ4 impeded the activation of nuclear factor kappa B (NF-κB) by inhibiting the phosphorylation of the inhibitory protein IκB. This action effectively prevented the production of proinflammatory cytokines like tumor necrosis factor-α (TNF-α), IL-1β, and IL-6. Furthermore, in a neonatal mouse model of fetal alcohol spectrum disorder, Tβ4 treatment demonstrated an inhibitory effect on the increase in inflammatory factors triggered by ethanol, leading to reduced expression levels of TNF-α and IL-1β.

Additional Information

SKUCL-THYMOSINB4FRAGMENT1/4-10MG

CategoryPeptides

Benefits

Please review the complete product description and available supporting documentation for product-specific research information. This product is sold strictly for laboratory research use.

Mechanism of Action

Refer to the product description, certificate of analysis and applicable published research for product-specific information. No medical or therapeutic claims are made.