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LL-37 Structure
Sequence: -Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-lle-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-GIn-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Molecular Formula: C205H340 N60O53
vMolecular Weight: 4493.342 g/mol
PubChem CID: 16198951
VCAS Number: 154947-66-7
Synonyms: CAP-18, Cathelicidin, antibacterial peptide LL-37
LL-37 stands as the sole recognized human cathelicidin within a sizable protein family known for its multifaceted functions. These peptides, primarily situated in macrophages and polymorphonuclear leukocytes (two types of white blood cells), hold significance in bacterial eradication while showcasing a range of other impactful effects. Often categorized as antimicrobial peptides (AMPs), this entire class demonstrates varied functions. LL-37 specifically contributes significantly to autoimmune disease, cancer, and the process of wound healing.
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